US grant · National Institutes of Health
BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)
Up to $700,000 Closes February 11, 2027
Official listing and how to apply
Source: Grants.gov · Last checked
Key facts
| Funder | National Institutes of Health |
|---|---|
| Part of | Department of Health and Human Services |
| Opportunity number | RFA-DC-27-004 |
| Amount per award | Up to $700,000 |
| Total funding available | $6,000,000 |
| Opens | May 4, 2026 |
| Closes | February 11, 2027 (93 days left) |
| Who can apply | Schools and universities, Businesses, Government, Nonprofits, Other (see listing), Tribal organizations |
| Applicant types listed | Independent school districts; County governments; Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; Native American tribal governments (Federally recognized); Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; City or township governments; For profit organizations other than small businesses; State governments; Private institutions of higher education; Small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments |
| State or area | Nationwide |
| Cost sharing or match | Not required |
| Status | Open |
| Source | Grants.gov |
| Last checked | November 10, 2026 |
About this grant
Summary from the official listing on Grants.gov:
Invasive surgical procedures in humans offer the unique opportunity to intracranially record and stimulate neuronal activity within precisely localized brain structures, enabling high-impact human neuroscience investigations. This NOFO seeks exploratory research projects, from newly formed or established multi-disciplinary teams, to understand how dynamic activity of single cells and ensembles of neurons in spatially organized networks gives rise to the internal states we experience as sensations, perceptions, emotions, thoughts, and memories, and to observable motor and social behaviors. The research should be proposed as exploratory research and planning activities to establish feasibility and early-stage development that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent research project grant applications using invasive neural recording and stimulation technologies in the human brain. Projects should maximize opportunities to conduct innovative in vivo human neuroscience research made available by direct access to the brain from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and by quantitative, mechanistic models where appropriate.
Recipients will join a consortium working group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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